Moreover, it has been a catalyst for the pharmaceutical industry to invest in further research into sexual health, leading to the development of other similar medications such as Cialis (tadalafil) and Levitra (vardenafil). The introduction of viagra dosage for 70 year old also had significant social and cultural impacts. It brought the topic of erectile dysfunction out of the shadows and into open discussion. Preliminary studies suggest that Viagra could help protect the heart from damage caused by certain chemotherapeutic agents, offering a new lease on life for cancer patients who are at risk of cardiac complications.
Moreover, viagra not working reddit ongoing research has been investigating the potential use of Viagra in other areas, such as the treatment of certain types of strokes and diseases characterized by excessive blood clotting. Other side effects may include headaches, flushing, indigestion, nasal congestion, dizziness, and visual disturbances. These side effects are generally mild and temporary but can be severe in rare cases. The use of Viagra is contraindicated in patients taking nitrates (often prescribed for chest pain), as the combination can cause a dangerous decrease in blood pressure.
Originally intended as a treatment for hypertension and angina pectoris, its notable side effect on erectile dysfunction (ED) redirected its course towards sexual health, marking a revolutionary step in its domain. Viagra, chemically known as sildenafil citrate, was first developed by scientists in Britain working for Pfizer in 1989. Its introduction was a major breakthrough and it has since become a cultural phenomenon, often discussed openly in the media and in popular culture, which was unusual for any medication related to sexual health before its advent.
Introduced to the market in 1998, Viagra was the first oral treatment approved by the FDA for erectile dysfunction. Sildenafil, under the brand name Revatio, is approved for the treatment of PAH, where it works by relaxing blood vessels in the lungs to allow blood to flow more easily. In addition to its primary use in erectile dysfunction, Viagra has also been explored for other medical conditions. For instance, it has shown potential benefits in treating pulmonary arterial hypertension (PAH), a serious condition characterized by high blood pressure in the arteries of the lungs.
Elevated levels of cGMP lead to smooth muscle relaxation and increased blood flow to the penis, facilitating the erection process. The mechanism of action of Viagra involves the enhancement of nitric oxide (NO) effects in the corpus cavernosum of the penis. Viagra works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which results in an increase in the levels of cyclic guanosine monophosphate (cGMP). NO is a natural chemical that relaxes muscles in the penis, increases blood flow, and allows for an erection in response to sexual stimulation.
The drug is effective only with sexual stimulation, as it relies on the initial release of nitric oxide by the body. By inhibiting PDE5, Viagra effectively increases the levels of cGMP, enhancing and prolonging erections in men suffering from ED. PDE5, however, breaks down cGMP, thus inhibiting the ability to achieve or maintain an erection.
